Nytt retrovirus forårsaker ME?
WPI med Judy A. Mikowits i spissen, offentliggjør oppsiktsvekkende forskningsresultater. Les publiseringen her
For oss som ikke har medisinsk bakgrunn er denne Q&A, besvart av Mikowits oppklarende:
1) Question: XMRV – Is this a new new virus?
Answer: Yes. prior to this paper showing XMRV is beyond a shadow of a doubt a Human infectious retrovirus, there are only two other human retroviral infections: HTLV1 and HIV
2) Question: Does XMRV cause CFS?
Answer: Both HTLV1 and HIV cause neurological disease and cancer. There is no symptom of CFS that cannot be explained by understanding the biology of this retrovirus. We will very soonhave enough data to say X satisfies the same correlAtes of disease association as HIVand AIDS. The 2/3 in the paper reflects active XMRV expression at the time we did the original screen. The p value for association of CFS with X is 10 -35; Virtually impossible to have CFS without XMRV. We still cannot say cause…in fact one cannot say cause for HIV AIDS but everyone knows what that means. Science is conservative so we cannot say cause but have accumulated significant data that will within the year allow us to satisfy Hill’s criteria of causality the main point of which is every case of the disease contains the pathogen.
3) Question: Do you have a test for the virus?
Answer: Since the submission of the manuscript on May 6th, we have developed a sensitive and specific seroconversion assay. We can detect antibodies to the XMRV envelope in>95% of the>250 patients we have tested from around the world. We have failed to call a case wrong either way.
4) Question: Are there effective treatment options on the horizon?
Answer: Because we have so many FDA approved antiretrovirals particularly non nucleoside RT inhibitors and integrase inhibitors as well as non steroidal antinflammatories. We see great promise of combination therapeutic strategies very quicklyIf an individual gets the immune system modulated to control and silence the virus the one can be well .The goal is to keep the virus quiet and the homeostasis as with the elite controllers of HIV. There are two GRE sites in the CIA acting elements of the virus. These respond to hormones and cortisol. By definition every positive patient is an AIDS patient
5) Reliability – Question: explain how the scientists react and the kind of authorities you have on your team…CFS patients have been disappointed a million times…is this for real?
Answer: John coffin is a member of the US National academy of Sciences. No greater authority on these viruses exists. 3 members of the US NAS reviewed this work and all are convinced of the science but need to be conservative so as not to scare the general public. They are convinced of the infection and the public health risk and our data suggest. 10 million Americans ate infected with XMRV and at a risk for CFS and cancer. For me it is crystal clear and all of the scientists who have seen these data have the same response: Absolute amazement. The best in the world are all over it. They may not understand CFS bug they understand an entirely new human disease entity ten fold the incidence of HIV!
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