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«Positive ‘XMRV-study’ is only a matter of time
Prague – May 3, 2010. Last October U.S. scientist presented a breakthrough around the research on chronic fatigue syndrome (CFS), which was published in Science. They found traces of the retrovirus XMRV in the blood of CFS patients. Thereafter, three groups of researchers, including one from Nijmegen, couldn’t confirm these findings. However, at the «Centennial Retrovirus Meeting» in Prague it became clear that the first positive ‘replication study’ seems only a matter of time.
The June issue of the journal Ortho will focus on the multi-day conference in Prague, which ends today. Especially in the corridors this new retrovirus was the talk of the day. Insiders agree that the negative XMRV studies which have been published so far, were not exact replication studies. These groups used techniques that differed too much from those used by the U.S. researchers. This is also true for a yet unpublished German study, where XMRV wasn’t found in blood samples from CFS patients either.
Recently the American scientist Dr. Judy Mikovits visited several European research groups to instruct them in the proper laboratory technique. It is now clear that these visits are starting to pay off. During the Prague Conference Mikovits explained once more in great detail the complex methodology of the Whittemore-Peterson Institute (WPI), the National Cancer Institute (NCI) and the Cleveland Clinic. This methodology of cultivating the virus is imperative because XMRV is only present in extremely low concentrations in the peripheral blood.
Dr. Francis Ruscetti of the renowned NCI – a U.S. government agency – told Ortho that he hopes this controversy will be over in 2011. He is especially surprised about the fact that the investigators of the UMC St. Radboud concealed in their publication that the Americans found traces of XMRV in the same blood samples from the Dutch patients. «I do not know how they think they get away with this ethically,» said Ruscetti. «I do not think this is good science.» Ruscetti pointed out again that the WPI, the NCI and the Cleveland Clinic applied four procedures in their research. «In the negative studies only one procedure was applied.» Ruscetti also ventilated his annoyance over what he calls the «whisper campaign» about contamination. According to the Nijmegen researchers, the Americans contaminated or polluted the Dutch blood samples.
Among others Ruscetti is supported by Prof. Dr. John Coffin, who is linked both to the NCI and Tufts University in Boston. He is considered one of the most prominent retrovirologists in the world. «People have raised the issue of contamination,» said Coffin. «But nothing is known about this. There is not a single shred of evidence to support these rumours. Much of the research is done at the NCI, in the laboratory of Francis and Sandra Ruscetti. They have a long experience with these viruses and are very cautious.»
Coffin emphasized once again that doing a replication study implies that it is performed in exactly the same way. «In none of the negative studies that have been published so far, the virus was grown,» said Coffin. ‘Only in the Science study this has been done, and that is a very strong point. »
Researchers from Nijmegen were not present at this leading conference.»