Rutts tankespinn og ME-nyheter

Det meste av det siste innen biomedisinsk forskning på ME

Amerikanske helsemyndigheter(FDA/NIH)s XMRV-studie nå online

Hentet fra prnewswire:

«Investigators from the U.S. Food and Drug Administration’s Center for Biologics Evaluation and Research and the National Institutes of Health Clinical Center, in collaboration with a physician scientist at Harvard Medical School, examined blood samples from 37 patients diagnosed with CFS and from 44 healthy blood donors.

MLV is a type of retrovirus known to cause cancer in mice. Several different MLV gene sequences were identified in samples from 32 of the 37 patients with CFS (87 percent) and 3 of the 44 (7 percent) healthy blood donors. Investigators performed DNA sequencing on all positively amplified samples to confirm MLV like gene sequences.

This study supports a previous investigation [Lombardi et al. Science October 23, 2009 326: 585] that showed XMRV, a genetic variant of MLV-like viruses, to be present in the blood of people with CFS. The study demonstrates a strong association between a diagnosis of CFS and the presence of MLV-like virus gene sequences in the blood.  The study also showed that MLV-like viral gene sequences were detected in a small fraction of healthy blood donors.  Although the statistical association with CFS is strong, this study does NOT prove that these retroviruses are the cause of CFS.  Further studies are necessary to determine if XMRV or other MLV-related viruses can cause CFS.»

Les det HER

———————————————–

Les publiseringen fra Proceedings of the National Academy of Science HER

Filene fra presentasjonen av studiet kan lastes ned HER

———————————————–

Hentet fra FDA.gov:

«Researchers have found murine leukemia viruses (MLV) related gene sequences in blood samples collected from patients diagnosed with chronic fatigue syndrome (CFS) and some healthy blood donors, according to a study published online today by the scientific journal Proceedings of the National Academy of Sciences (PNAS).

Investigators from the U.S. Food and Drug Administration’s Center for Biologics Evaluation and Research and the National Institutes of Health Clinical Center, in collaboration with a physician scientist at Harvard Medical School, examined blood samples from 37 patients diagnosed with CFS and from 44 healthy blood donors.

MLV is a type of retrovirus known to cause cancer in mice. Several different MLV gene sequences were identified in samples from 32 of the 37 patients with CFS (87 percent) and 3 of the 44 (7 percent) healthy blood donors. Investigators performed DNA sequencing on all positively amplified samples to confirm MLV like gene sequences.

This study supports a previous investigation [Lombardi et al. Science October 23, 2009 326: 585] that showed XMRV, a genetic variant of MLV-like viruses, to be present in the blood of people with CFS.  The study demonstrates a strong association between a diagnosis of CFS and the presence of MLV-like virus gene sequences in the blood.  The study also showed that MLV-like viral gene sequences were detected in a small fraction of healthy blood donors.»

Les det HER

—————————————————-

Hentet fra WSJ.com:

«Researchers said Monday they have identified a family of retroviruses in patients with chronic fatigue syndrome, a finding that is likely to spur patients with the condition to seek treatment with drugs used to fight HIV, the virus that causes AIDS.

The report, published in the Proceedings of the National Academy of Sciences, was accompanied by a call for new clinical trials to test HIV drugs in patients with chronic fatigue syndrome, which afflicts an estimated one million to four million Americans and as many as 17 million people world-wide.

Although HIV and the newly identified virus group are different, both are retroviruses. Based on other recent research linking CFS to a retrovirus called XMRV, some doctors are already prescribing drugs approved for HIV for CFS patients. The syndrome has no known cause and there aren’t any effective treatments.»

Les det HER

——————————————————–

Hentet fra NYTimes.com:

«Now a second research team has reported a link between the fatigue syndrome and the same class of virus, a category known as MRV-related viruses. In a paper published Monday by The Proceedings of the National Academy of Sciences, scientists found gene sequences from several MRV-related viruses in blood cells from 32 out of 37 chronic-fatigue patients but only 3 of 44 healthy ones.»

Les mer HER

—————————————————–

Hentet fra washingtonpost.com:

«A well-respected team of scientists released long-awaited new evidence Monday that a virus may be playing a role in chronic fatigue syndrome.

The researchers, from the National Institutes of Health, the Food and Drug Administration and Harvard Medical School, analyzed blood samples that had been collected 15 years ago from 37 patients with chronic fatigue syndrome. Most of the subjects–32, or 86.5 percent–tested positive for a virus known as a murine leukemia virus-related virus, the researchers found. In contrast, tests on 44 healthy blood donors detected evidence of the virus in only three of the subjects, or 6.8 percent.»

Les mer HER

————————————————————-

Hentet fra scientificamerica.com;

«The perplexing condition known as chronic fatigue syndrome (CFS) might be linked to infection with a retrovirus, report the authors of a new paper published this week inProceedings of the National Academy of Sciences (PNAS).»

Les mer HER

—————————————-

Hentet fra latimes.com:

«Government scientists have found traces of a mouse-relatedvirus in 86% of patients with chronic fatigue syndrome, a discovery that is likely to reignite the controversy surrounding the virus widely known as XMRV»

Les artikkelen HER

———————————————————–

Hentet fra sciencemag.org:

«There’s a new twist in the ongoing battle over whether a virus is linked to chronic fatigue syndrome (CFS). After the journal held it for 2 months, a study supporting a link between a mouse retrovirus and CFS was published today in the Proceedings of the National Academy of Science (PNAS). Many are still doubtful of the link, but they’re impressed by the authors’ efforts to ensure accuracy.»

Les artikkelen HER

————————————————————

Hentet fra dailymail.co.uk:

«Chronic fatigue syndrome may be caused by a rare mouse-related virus, new research suggests.

Scientists found evidence of murine leukaemia virus – known to cause cancer in mice – in 86 per cent of chronic fatigue patients.

However, traces from this family of bugs were only found in seven per cent of samples from healthy blood donors.

It adds to the growing body of evidence that an infection could play a role in the complicated illness.»

Les artikkelen HER

———————————————————-

Hentet fra webmd.com:

«The new study shows that 86.5% of 37 people with CFS had evidence of this virus in their blood, as did 6.8% healthy blood donors. These findings back up a recent report by researchers at the Whitemore Peterson Institute in Reno, Nev., which showed similar results

Les artikkelen HER

——————————————-

Hentet fra medscape.com:

«August 24, 2010 — Scientists from the U.S. Food and Drug Administration’s (FDA’s) Center for Biologics Evaluation and Research and the National Institutes of Health (NIH) have found murine leukemia virus (MLV)–related gene sequences in patients with chronic fatigue syndrome (CFS) and in some healthy blood donors.»

Les artikkelen HER

————————————————

Hentet fra newscientist.com:

«Instead, Shyh-Ching Lo of the Food and Drug Administration in Bethesda, Maryland, and colleagues found that blood samples from 32 of 37 people with chronic fatigue syndrome contained «polytropic» murine leukaemia virus-related fragments, compared with only three of 44 healthy blood donors.»

Les artikkelen HER

7 responses to “Amerikanske helsemyndigheter(FDA/NIH)s XMRV-studie nå online

  1. Andreas 23.08.10, kl. 19:28

    Takk for oppdateringer Rutt. Nesten som en RSSfeed dette her.

    Nå braker det løs for alvor. Nå får alle psykologforeningsponsede oppfølgingsstudier som ikke har funnet noe som helst, inludert CDC, et forklaringsproblem.

    Dette kommer til å ta helt av nå. Spørsmålene er jo om det er årsaken, en av årsakene, eller bare nok et virus som blir aktivert/reaktivert av denne sykdommen. Uansett er det blest, bevegelse og handling på trappene. Spennende.

  2. selsius 23.08.10, kl. 19:31

    CDC sitter grunn i sitt eget klister etter dette. De har jo total brukt opp det de måtte ha av troverdighet. Hvordan er det mulig og ta CDC på alvor etter dette? Da må de krype til korset og rydde opp i all offentlighet, uansett hva dette måtte bety i forhold til ME/CFS.

  3. Jannik 23.08.10, kl. 19:38

    Jeg blir helt svimmer her nå. Dem fant ikke XMRV, men et lignende virus; MLV. Og dem fant 5 munterte versioner?!? Og det kan gjemme seg i krops vev, uten å påvises i blod. Synes dette er triste nyheter, men samtidig bra at dem finner ut dette. Svaret er nok ganske komplisert til slutt🙂 Ser nok bare toppen av isfjellet.

  4. Inger Johanne 23.08.10, kl. 19:45

    En stor dag. Etter 9 år i senga eller på sofan er dette svært så velkommen nyheter. Bare at håpet er til stede for at jeg en dag skal kunne føle meg bedre er stort, og nå er vi nærmere.

  5. Inger Johanne 23.08.10, kl. 20:33

    Fantastisk jobb i kveld, Rutt.

  6. Rutt 23.08.10, kl. 21:46

    Takk for kommentarer!
    Først og fremst genererer dette sannsynligvis midler til forskning! Deretter er det banebrytende ifh til å anerkjenne ME som en alvorlig fysiologisk sykdom hvor den syke har krav på utredning og behandling, ikke en psykologisk tilstand man selv har ansvaret for å tenke seg ut av. Alt dette er et godt stykke videre på vegen, jeg er optimistisk og tror vi har spennende tider i møte🙂

    Klem Rutt

  7. Pingback: Video 25.08: Vegard Brun Wyller uttaler seg om ME og XMRV på TV2 Nyhetskanalen « Rutts tankespinn og ME-nyheter

Legg igjen en kommentar

Fyll inn i feltene under, eller klikk på et ikon for å logge inn:

WordPress.com-logo

Du kommenterer med bruk av din WordPress.com konto. Logg ut / Endre )

Twitter picture

Du kommenterer med bruk av din Twitter konto. Logg ut / Endre )

Facebookbilde

Du kommenterer med bruk av din Facebook konto. Logg ut / Endre )

Google+ photo

Du kommenterer med bruk av din Google+ konto. Logg ut / Endre )

Kobler til %s

%d bloggers like this: