Rutts tankespinn og ME-nyheter

Det meste av det siste innen biomedisinsk forskning på ME

Referat fra ME-konferanse i Australia 3-4 desember

XMRV Global Action har lagt ut et langt referat på sin Facebookside HER.

For de som ikke har tilgang til Facebook har jeg kopiert det inn i et PDF-dokument som kan leses HER

Kan leses på norsk med Google Translater HER

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Det var mange forskere som presenterte sine funn på denne konferansen. Jeg velger å legge ut referatet fra Prof. De Meirleirs innlegg:

«Kenny de Meirlier (Brussels, Belgium): Because chronic activation of the immune system is present in progressive HIV and is a better predictor of disease outcome than viral load, it is important to test the hypothesis that a similar pattern may be observed in XMRV positive CFS patients. 16 XMRV positive patients (using culture assay) had a large number of tests performed. These patients were found to have reduced lymphocyte numbers and CD-57+lymphocytes reduced, as observed in HIV. There was evidence of an activated innate immune system (increased elastase activity and C4a). sCD14 was significantly higher than expected, and this correlated with plasma lipopolysaccharide (LPS) a proinflammatory component of the gram-negative bacterial envelope. Low stool IgA indicated dysfunctional mucosa-associated lymphomal tissue in XMRV positive patients. Serum IL-8,IL-10,MCP-1 and MIP-1‚ are increased and might constitute a biological signature for viral infection.

This all provides supportive evidence for microbial translocation being part of the pathology of XMRV +ve patients.

He described a Norwegian study of severely disabled CFS patients in which the plasma LPS was elevated in those with a low Karnofsky score. This suggests a leaky gut syndrome. Stool analysis in CFS patients has indicated overgrowth of enterococci, streptococci and fungi with diminished E.Coli count. This can lead to overproduction of hydrogen sulphide which is toxic to mitochondria and affects ATP.»

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