Studie om biologiske mekanismer ved utmattelsestilstander fra Stavanger Universitetssykehus publisert i Rheumatology
Hentet fra Rheumatology:
«Biological mechanisms of chronic fatigue
- Katrine B. Norheim1,
- Grete Jonsson2 and
- Roald Omdal1,3
+ Author Affiliations
Correspondence to: Roald Omdal, Department of Internal Medicine, Clinical Immunology Unit, Stavanger University Hospital, PO Box 8100 Forus, 4068 Stavanger, Norway. E-mail: email@example.com
Received October 21, 2010.
1Department of Internal Medicine, Clinical Immunology Unit, 2Department of Medical Biochemistry, Stavanger University Hospital, Stavanger and 3Institute of Internal Medicine, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
Revision received December 14, 2010.
Chronic fatigue is a common, poorly understood and disabling phenomenon in many diseases. We aim to provide an overview of fatigue in chronic autoimmune and inflammatory disease. Fatigue measurement, prevalence and confounding factors such as depression, sleep disorders and pain are reviewed in the first half of the article. In the second half of the article, we describe explanatory models of fatigue and fatigue signalling, with an emphasis on cytokines and sickness behaviour, oxidative stress, mitochondrial dysfunction and the impact of certain genes on fatigue.»
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